The Proflate Elite works with many different CO2 cartridge sizes like 12 gram threaded, 16 gram threaded & non-threaded, 20 gram threaded, 25 gram threaded. Innovations built in their EZ Connect Technology to the built in all-weather nozzle cover. The Proflate Elite is loaded with features that makes inflation safer and easier. Simply drop the cartridge into the cup (or screw cartridge into the head of inflator), attach the head, press onto valve stem, pull trigger and begin controllable inflation. Easy enough to use with one hand, it will get your tire up to desired pressure in seconds. If you use something other than a 16g cartridge, you will need to forgo the body and just use the head.